VPS36

VPS36

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2HTH, 2ZME, 3CUQ

Identifiers

VPS36, C13orf9, EAP45, CGI-145, vacuolar protein sorting 36 homolog

External IDs

MGI: 1917410 HomoloGene: 9374 GeneCards: VPS36

Gene ontology
Molecular function	• phosphatidylinositol-3-phosphate binding • protein C-terminus binding • ubiquitin binding • protein binding • lipid binding
Cellular component	• cytoplasm • cytosol • late endosome • membrane • late endosome membrane • lysosome • extracellular exosome • nucleus • ESCRT II complex • endosome
Biological process	• regulation of transcription, DNA-templated • multivesicular body assembly • transcription, DNA-templated • autophagy • endosomal transport • transport • protein transport • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


51028


70160


ENSG00000136100


ENSMUSG00000031479


Q86VN1


Q91XD6

RefSeq (mRNA)


NM_016075 NM_001282168 NM_001282169


NM_027338

RefSeq (protein)


NP_001269098.1 NP_057159.2


NP_081614.1

Location (UCSC)

Chr 13: 52.41 – 52.45 Mb

Chr 8: 22.19 – 22.22 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
↑ Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem. 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.
↑ "Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

Further reading

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding.". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
Alam SL, Langelier C, Whitby FG, et al. (2007). "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.". Nat. Struct. Mol. Biol. 13 (11): 1029–30. doi:10.1038/nsmb1160. PMID 17057716.

PDB gallery

2dx5: The complex structure between the mouse EAP45-GLUE domain and ubiquitin

2hth: Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain

This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.