Vernolepin

Vernolepin
Names
IUPAC name
(3aR,4S,5aR,9aR,9bR)-4-Hydroxy-3,9-bis(methylene)-5a-vinyloctahydro-2H-furo[2,3-f]isochromene-2,8(3H)-dione
Systematic IUPAC name
(3aR,4S,5aR,9aR,9bR)-4-Hydroxy-3,9-bis(methylene)-5a-vinyloctahydro-2H-furo[2,3-f]isochromene-2,8(3H)-dione
Other names
Vernolepin
Identifiers
18542-37-5
3D model (Jmol) Interactive image
ChemSpider 390780
KEGG C09582
PubChem 442322
Properties
C15H16O5
Molar mass 276.29 g·mol−1
Melting point 179 to 180 °C (354 to 356 °F; 452 to 453 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Vernolepin is a sesquiterpene lactone isolated from the dried fruit of Vernonia amygdalina. It shows platelet anti-aggregating properties[2] and is also an irreversible DNA polymerase inhibitor,[3] hence may have antitumor properties.

References

  1. Laekeman, G. M.; Mertens, J.; Totté, J.; Bult, H.; Vlietinck, A. J.; Herman, A. G. (1 March 1983). "Isolation and Pharmacological Characterization of Vernolepin". Journal of Natural Products. 46 (2): 161–169. doi:10.1021/np50026a003.
  2. Laekeman, G. M.; Clerck, F.; Vlietinck, A. J.; Herman, A. G. (1 January 1985). "Vernolepin: An antiplatelet compound of natural origin". Naunyn-Schmiedeberg's Archives of Pharmacology. 331 (1): 108–113. doi:10.1007/BF00498859.
  3. Clayden, Jonathan (2005). Organic chemistry (Reprinted (with corrections). ed.). Oxford [u.a.]: Oxford Univ. Press. p. 238. ISBN 978-0-19-850346-0.
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