Zucapsaicin

Zucapsaicin
Clinical data

Trade names	Civanex
Routes of administration	Topical
ATC code	M02AB02 (WHO)
Identifiers
IUPAC name (Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Synonyms	Civamide; (Z)-Capsaicin; cis-Capsaicin
CAS Number	25775-90-0
PubChem (CID)	1548942
ChemSpider	1265956
UNII	15OX67P384
ECHA InfoCard	100.164.527
Chemical and physical data
Formula	C₁₈H₂₇NO₃
Molar mass	305.41188 g/mol
3D model (Jmol)	Interactive image
SMILES Oc1ccc(cc1OC)CNC(CCCC\C=C/C(C)C)=O
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6- Key:YKPUWZUDDOIDPM-VURMDHGXSA-N

Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).^[1]

Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis.^[2]

References

↑ Winston Pharmaceuticals website "Archived copy". Archived from the original on April 25, 2012. Retrieved November 16, 2011.
↑ Zucapsaicin information from the National Library of Medicine http://druginfo.nlm.nih.gov/drugportal

Topical products for joint and muscular pain (M02)

Anti-inflammatory
preparations,
non-steroids

Pyrazolidines	Clofezone Mofebutazone Oxyphenbutazone Phenylbutazone

Acetic acid derivatives	Diclofenac Fentiazac Tolmetin

Other	Bendazac Benzydamine Bufexamac Etofenamate Felbinac Feprazone Flurbiprofen Ibuprofen Indometacin Ketoprofen Meclofenamic acid Naproxen Nifenazone Niflumic acid Piketoprofen Piroxicam Suxibuzone

Capsaicin derivatives

Zucapsaicin

Other

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