DEFA3

Defensin 3, dimer, Human.

DEFA3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1DFN, 1ZMH, 1ZMI, 1ZMK, 2PM4, 2PM5
Identifiers
Aliases	DEFA3, DEF3, HNP-3, HNP3, HP-3, HP3, defensin alpha 3
External IDs	HomoloGene: 128756 GeneCards: DEFA3
Gene ontology Molecular function • molecular function Cellular component • extracellular region • extracellular exosome • azurophil granule lumen • extracellular space • Golgi lumen Biological process • defense response to fungus • defense response to Gram-positive bacterium • intracellular estrogen receptor signaling pathway • defense response to bacterium • innate immune response in mucosa • antibacterial humoral response • defense response • defense response to virus • killing of cells of other organism • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1668	n/a
Ensembl	ENSG00000239839	n/a
UniProt	P59666	n/a
RefSeq (mRNA)	NM_005217	n/a
RefSeq (protein)	NP_005208.1	n/a
Location (UCSC)	Chr 8: 7 – 7.02 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene.^[2] Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.

Function

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.^[2]

References

Further reading

PDB gallery
1zmh: Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)  1zmk: Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group  2pm4: Human alpha-defensin 1 (multiple Arg->Lys mutant)  2pm5: Human alpha-defensin 1 derivative (HNP1)  1dfn: CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION  2pm1: Derivative of human alpha-defensin 1 (HNP1)  1zmi: Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group )

This article incorporates text from the United States National Library of Medicine, which is in the public domain.