List of adverse effects of paroxetine

This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.^[1][2][3][4]

Very common

Very common (>10% incidence) adverse effects include:

• Nausea
• Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.^[5]
• Impaired concentration
• Somnolence is more common with paroxetine than with other SSRIs.^[6]
• Insomnia
• Headache
• Dry mouth

Common

Common (1–10% incidence) adverse effects include:

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

Rare

Rare (0.01–0.1% incidence) adverse effects include:

Very rare

Rare (<0.01% incidence) adverse effects include:

• Thrombocytopenia
• Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
• Serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor)^[17][18]
• Gastrointestinal bleeding
• Hepatic events (such as hepatitis, sometimes associated with jaundice and/or liver failure)
• Priapism
• Severe cutaneous adverse reactions (including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis)
• Photosensitivity reactions

References