Tribendimidine

Tribendimidine
Clinical data

ATC code	none
Identifiers
IUPAC name N,N'-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4 -phenylene dimethylidyneamine
CAS Number	115103-15-6^N
PubChem (CID)	3086564
ChemSpider	2343161^Y
ChEMBL	CHEMBL427256^N
Chemical and physical data
Formula	C₂₈H₃₂N₆
Molar mass	452.594 g/mol
3D model (Jmol)	Interactive image
SMILES N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3
InChI InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+^Y Key:XOIOGKHKNQYULW-HTNNXBMUSA-N^Y
^NY (what is this?) (verify)

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.^[1]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.^[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.^[1]

Tribendimidine is associated with Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China.

References

1 2 Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother. 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
↑ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

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