HLA-B*83

major histocompatibility complex (human), class I, B*83
Alleles B*8301
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B**8301
Locus chr.6 6p21.31

HLA-B*83 (B83) is an HLA-B allele-group composed of a single allele, B*8301. There is no useful serology associated with this allele.[1]

Further information: HLA-serotype tutorial

It is found in a single Mbenzele Pygmy tribe of the Central Africa Republic at 1.5%.[2] B*8301 appears to be the result of the replacement of exon 2 from B*4402 with exon 2 from B*5603.[3] (For terminology help see: HLA-serotype tutorial)

Location of Central African Republic
Location of Africa's Pygmy Tribes

References

  1. Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. Bruges Armas J, Destro-Bisol G, López-Vazquez A, et al. (2003). "HLA class I variation in the West African Pygmies and their genetic relationship with other African populations". Tissue Antigens. 62 (3): 233–42. doi:10.1034/j.1399-0039.2003.00100.x. PMID 12956877.
  3. Steiner NK, Gans CP, Kosman C, et al. (2001). "New alleles in the B44 family including B*44022, B*44032, B*4411, B*4420, B*4421, B*4424, and B*8301". Tissue Antigens. 57 (4): 376–9. doi:10.1034/j.1399-0039.2001.057004376.x. PMID 11380952.
This article is issued from Wikipedia - version of the 9/1/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.