HLA-B75

Further information: HLA-serotype tutorial
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B75
Alleles B*1513
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]

B75 is one of many split antigens of the broad antigen, B15. B75 (B*1502) is associated with a severe drug-induced skin condition in ethnic East Asians.[2]

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA-B*15 gene products[3]
B*15 B15 B62 B63 B70 B71 B72 B75 B76 B77 Sample
allele % % % % % % % % % size (N)
*1502 7 22 62 1035
*1521 7 12 55 132
Alleles link-out to IMGT/HLA Database at EBI

Alleles

HLA B*1502 frequencies
freq
ref. Population (%)
[4] Philippines Ivatan22.0
Taiwan Puyuma18.0
China Guangxi Maonan14.8
China Yunnan Lisu12.3
Taiwan Tao12.0
Singapore Chinese Han11.6
China Guangzhou11.0
Hong Kong Chinese10.2
China Yunnan Nu9.0
Singapore Riau Malay8.4
Singapore Javanese Indonesians8.2
Thailand (3)8.2
China South Han7.1
Singapore Thai6.1
India Khandesh Pawra6.0
Taiwan Minnan pop 15.9
Singapore Chinese5.7
India West Bhils4.0
Taiwan Pazeh3.6
China Guangdong Meizhou Han3.5
South Africa Natal Tamil3.1
China Qinghai Hui2.7
Taiwan Hakka2.7
Shijiazhuang Tianjian Han2.4
China North Han1.9
India Mumbai Marathas1.9
India North Delhi1.6
China Beijing1.5
China Inner Mongolia1.5
American Samoa1.0
India North Hindus1.0
Taiwan Siraya1.0
Taiwan Tsou1.0
Ingig. Australian Groote Eylandt0.7
United Arab Emirates0.6
HLA B*1521 frequencies
freq
ref. Population (%)
[4] Indig. Australian Cape York Penin.13.5
Indig. Australian Yuendumu12.4
PNG Eastern Highlands Goroka7.1
Ind. Australian Groote Eylandt6.0
New Caledonia5.8
Singapore Riau Malay4.0
American Samoa3.0
Australian Aborigine Kimberly2.6
PNG Karimui Plateau2.5
Singapore Javanese Indonesians2.0
Papua New Guinea Wanigela1.5
USA Asian1.4
Philippines Ivatan1.0
Thailand (3)1.0
Taiwan Hakka0.9

Diseases

HLA-B*1502 is associated with Carbamazepine and phenytoin induced Stevens–Johnson syndrome in Chinese and Thai.[2][5][6] One study showed a 100% association between B*1502 and the drug induced skin disorder in Chinese.[5] In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol.

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. 1 2 Chung WH, Hung SI, Hong HS, et al. (April 2004). "Medical genetics: a marker for Stevens–Johnson syndrome". Nature. 428 (6982): 486. doi:10.1038/428486a. PMID 15057820.
  3. ↑ derived from IMGT/HLA
  4. 1 2 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)
  5. 1 2 Locharernkul C, Loplumlert J, Limotai C, et al. (July 2008). "Carbamazepine and phenytoin induced Stevens–Johnson syndrome is associated with HLA-B*1502 allele in Thai population". Epilepsia. 49 (12): 2087–91. doi:10.1111/j.1528-1167.2008.01719.x. PMID 18637831.
  6. ↑ Man CB, Kwan P, Baum L, et al. (May 2007). "Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese". Epilepsia. 48 (5): 1015–8. doi:10.1111/j.1528-1167.2007.01022.x. PMID 17509004.
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